Human experiments: nonconsensual medical experiments on human beings.
“The mere mention of experimental medical research on incapacitated
human beings – the mentally ill, the profoundly retarded, and minor
children – summons up visceral reactions, with recollections of the
brutal Nazi experimentation…
Even without the planned brutality, we have had deplorable
instances of over-reaching medical research in this country.”
Justice Edward Greenfield
T.D. v. NYSOMH, 1995
A Chronology of Human Research
A History of US Secret Human Experimentation
Human Experimentation – Before the Nazi Era and After
The Nuremberg Code (1947)
A Chronology of Human Research from
6th century B.C.: Meat and vegetable experiment on young Jewish
prisoners in Book of Daniel.
5th century B.C: “Primum non nocere” (“First do no harm”), medical
ethics standard attributed to Hippocrates. This Oath became
obligatory for physicians prior to practicing medicine in the 4th
1st century B.C. Cleopatra devised an experiment to test the
accuracy of the theory that it takes 40 days to fashion a male
fetus fully and 80 days to fashion a female fetus. When her
handmaids were sentenced to death under government order, Cleopatra
had them impregnated and subjected them to subsequent operations to
open their wombs at specific times of gestation.
12th century: Rabbi and physician Maimonides’ Prayer: “May I never
see in the patient anything but a fellow creature in pain.”
1796: Edward Jenner injects healthy eight-year-old James Phillips
first with cowpox then three months later with smallpox and is
hailed as discoverer of smallpox vaccine.
1845-1849: J. Marion Sims, “the father of gynecology” performed
multiple experimental surgeries on enslaved African women without
the benefit of anesthesia. After suffering unimaginable pain, many
lost their lives to infection. One woman was made to endure 34
experimental operations for a prolapsed uterus.
1865: French physiologist Claude Bernard publishes “Introduction to
the Study of Human Experimentation,” advising: “Never perform an
experiment which might be harmful to the patient even though highly
advantageous to science or the health of others.”
1896: Dr. Arthur Wentworth performed spinal taps on 29 children at
Children’s Hospital, Boston, to determine if the procedure was
harmful. Dr. John Roberts of Philadelphia, noting the non-
therapeutic indication, labeled Wentworth’s procedures “human
1897: Italian bacteriologist Sanarelli injects five subjects with
bacillus searching for a causative agent for yellow fever.
1900: Walter Reed injects 22 Spanish immigrant workers in Cuba with
the agent for yellow fever paying them $100 if they survive and
$200 if they contract the disease.
1900: Berlin Code of Ethics. Royal Prussian Minister of Religion,
Education, and Medical Affairs guaranteed that:
“all medical interventions for other than diagnostic, healing, and
immunization purposes, regardless of other legal or moral
authorization are excluded under all circumstances if, the human
subject is a minor or not competent due to other reasons;
the human subject has not given his unambiguous consent; the
consent is not preceded by a proper explanation of the possible
negative consequences of the intervention.”
1906: Dr. Richard Strong, a professor of tropical medicine at
Harvard, experiments with cholera on prisoners in the Philippines
1913: Pennsylvania House of Representatives recorded that 146
children had been inoculated with syphilis, “through the courtesy
of the various hospitals” and that 15 children in St. Vincent’s
House in Philadelphia had had their eyes tested with tuberculin.
Several of these children became permanently blind. The
experimenters were not punished.
1915: A doctor in Mississippi, working for the U.S. Public Health
Office produces Pellagra in twelve Mississippi inmates in an
attempt to discover a cure for the disease
1919-1922: Testicular transplant experiments on five hundred
prisoners at San Quentin.
1927: Carrie Buck of Charlottesville is legally sterilized against
her will at the Virginia Colony Home for the Mentally Infirm.
Carrie Buck was the mentally normal daughter of a mentally retarded
mother, but under the Virginia law, she was declared potentially
capable of having a “less than normal child.”
By the 1930s, seventeen states in the U.S. have laws permitting
forced sterilization The settlement of Poe v. Lynchburg Training
School and Hospital (same institution, different name) in 1981
brought to an end the Virginia law. It is estimated that as many as
10,000 perfectly normal women were forcibly sterilized for “legal”
reasons including alcoholism, prostitution, and criminal behavior
1931: Lubeck, Germany, 75 children die in from pediatrician’s
experiment with tuberculosis vaccine.
1931: Germany adopts “Regulation on New Therapy and
Experimentation” requiring all human experiments to be preceded by
animal experiments. This law remained in effect during the Nazi
1931: Dr. Cornelius Rhoads, a pathologist, conducted a cancer
experiment in Puerto Rico under the auspices of the Rockefeller
Institute for Medical Investigations. Dr. Rhoads has been accused
of purposely infecting his Puerto Rican subjects with cancer cells.
Thirteen of the subjects died. A Puerto Rican physician uncovered
the experiment an investigation covered-up the facts.
Despite Rhoads’ hand written statements that the Puerto Rican
population should be eradicated, Rhoads went on to establish U.S.
Army Biological Warfare facilities in Maryland, Utah, and Panama,
and was later named to the U.S. Atomic Energy Commission. Rhoads
was also responsible for the radiation experiments on prisoners,
hospital patients, and soldiers. The American Association for
Cancer Research honored him by naming its exemplary scientist award
the Cornelius Rhoads Award.
1932-1972: U.S. Public Health Service study in Tuskegee, Alabama of
more than 400 black sharecroppers observed for the natural course
of untreated syphilis.
1932: Japanese troops invade Manchuria. Dr. Shiro Ishii, a
prominent physician and army officer begins preliminary germ
1936: Japan’s Wartime Human Biowarfare Experimentation Program.
1938: Japan establishes Unit 731 in Pingfan, 25 km. from Harbin.
Unit 731, a biological-warfare unit disguised as a water-
purification unit, is formed outside the city of Harbin.
1939: Third Reich orders births of all twins be registered with
Public Health Offices for purpose of genetic research.
1939: Twenty-two children living at the Iowa Soldiers’ Orphans’
Home in Davenport were the subjects of the “monster” experiment
that used psychological pressure to induce children who spoke
normally to stutter. It was designed by one of the nation’s most
prominent speech pathologists, Dr. Wendell Johnson, to test his
theory on the cause of stuttering.
1940: Poisonous gas experiments at Unit 731. One experiment
conducted September 7-10, 1940, on 16 Chinese prisoners who were
exposed to mustard gas in a simulated battle situation.
1940-1941: Unit 731 used aircraft to spread cotton and rice husks
contaminated with the black plague at Changde and Ningbo, in
central China. About 100 people died from the black plague in
Ningbo as a result.
1940’s: In a crash program to develop new drugs to fight Malaria
during World War II, doctors in the Chicago area infected nearly
400 prisoners with the disease. Although the Chicago inmates were
given general information that they were helping with the war
effort, they were not informed about the nature of the experiment.
Nazi doctors on trial at Nuremberg cited the Chicago studies as
precedents to defend their own research aimed at aiding the German
1941: Sterilization experiments at Auschwitz.
1941-1945: Typhus experiments at Buchenwald and Natzweiler
1941: Dr. William c. Black inoculated a twelve month old baby with
herpes. He was criticized by Francis Payton Rous, editor of the
Journal of Experimental Medicine, who called it “an abuse of power,
an infringement of the rights of an individual, and not excusable
because the illness which followed had implications for science.”
Dr. Rous rejected outright the fact that the child had been
“offered as a volunteer.”
1942 – 1945: Unit 731. Ishii begins “field tests” of germ warfare
and vivisection experiments on thousands of Chinese soldiers and
civilians. Chinese people who rebelled against the Japanese
occupation were arrested and sent to Pingfan where they became
human guinea pigs; there is evidence that some Russian prisoners
were also victims of medical atrocities.
“I cut him open from the chest to the stomach and he screamed
terribly and his face was all twisted in agony. He made this
unimaginable sound, he was screaming so horribly. But then finally
he stopped. This was all in a day’s work for the surgeons, but it
really left an impression on me because it was my first time.” NYT
These prisoners were called ‘maruta’ (literally ‘logs’) by the
Japanese. After succumbing to induced diseases – including bubonic
plague, cholera, anthrax – the prisoners were usually dissected
while still alive, their bodies then cremated within the compound.
Tens of thousands died. The atrocities were committed by some of
Japan’s most distinguished doctors recruited by Dr. Ishii.
1942: High altitude or low pressure experiments at Dachau
1942: Harvard biochemist Edward Cohn injects sixty-four
Massachusetts prisoners with beef blood in U.S. Navy-sponsored
1942: Japanese sprayed cholera, typhoid, plague, and dysentery
pathogens in the Jinhua area of Zhejian province (China). A large
number of Japanese soldiers also fell victim to the sprayed
1942-1943: Bone regeneration and transplantation experiments on
female prisoners at Ravensbrueck concentration camp.
1942-1943: Freezing experiments at Dachau concentration camp.
1943: Refrigeration experiment conducted on sixteen mentally
disabled patients who were placed in refrigerated cabinets at 30
degree Farenheit, for 120 hours, at University of Cincinnati
Hospital., “to study the effect of frigid temperature on mental
1942-1943: Coagulation experiments on Catholic priests at Dachau
1942-1944: U.S. Chemical Warfare Service conducts mustard gas
experiments on thousands of servicemen.
1942-1945: Malaria experiments at Dachau concentration camp on more
than twelve hundred prisoners.
1943: Epidemic jaundice experiments at Natzweiler concentration
1943-1944: Phosphorus burn experiments at Buchenwald concentration
1944: Manhattan Project injection of 4.7 micrograms of plutonium
into soldiers at Oak Ridge.
1944: Seawater experiment on sixty Gypsies who were given only
saltwater to drink at Dachau concentration camp.
1944-1946: University of Chicago Medical School professor Dr. Alf
Alving conducts malaria experiments on more than 400 Illinois
1945: Manhattan Project injection of plutonium into three patients
at Billings Hospital at University of Chicago.
1945: Malaria experiment on 800 prisoners in Atlanta.
1946: Opening of Nuremberg Doctors Trial by U.S. Military Tribunal.
1945: Japanese troops blow up the headquarters of Unit 731 in final
days of Pacific war. Ishii orders 150 remaining “logs” (i.e., human
beings) killed to cover up their experimentation. Gen. Douglas
MacArthur is named commander of the Allied powers in Japan.
1946: U.S. secret deal with Ishii and Unit 731 leaders cover up of
germ warfare data based on human experimentation in exchange for
immunity from war-crimes prosecution.
1946-1953: Atomic Energy Commission sponsored study conducted at
the Fernald school in Massachusetts. Residents were fed Quaker Oats
breakfast cereal containing radioactive tracers.
1946: Patients in VA hospitals are used as guinea pigs for medical
experiments. In order to allay suspicions, the order is given to
change the word “experiments” to “investigations” or “observations”
whenever reporting a medical study performed in one of the nation’s
1947: Colonel E.E. Kirkpatrick of the U.S. Atomic Energy Commission
issues a secret document (Document 07075001, January 8, 1947)
stating that the agency will begin administering intravenous doses
of radioactive substances to human subjects.
1947: The CIA begins its study of LSD as a potential weapon for use
by American intelligence. Human subjects (both civilian and
military) are used with and without their knowledge.
1947: Judgment at Nuremberg Doctors Trial sets forth “Permissible
Medical Experiments” – i.e., the Nuremberg Code, which begins: “The
voluntary consent of the human subject is absolutely essential.”
1949: Intentional release of radiodine 131 and xenon 133 over
Hanford Washington in Atomic Energy Commission field study called
1949: Soviet Union’s war crimes trial of Dr. Ishii’s associates.
1949-1953: Atomic Energy Commission studies of mentally disabled
school children fed radioactive isotopes at Fernald and Wrentham
1940s-1950s: “psychic driving” and “mental departterning”
experiments conducted by Dr. Ewen Cameron, depriving patients of
sleep, using massive ECT combined with psychoactive drugs such as,
LSD. After his “treatments” patients were unable to function. In
the 1950’s Dr.Cameron’s experiments were sponsored by the CIA.
1950: Dr. Joseph Stokes of the University of Pennsylvania infects
200 women prisoners with viral hepatitis. 1950: U.S. Army secretly
used a Navy ship outside the Golden Gate to spray supposedly
harmless bacteria over San Francisco and its outskirts. Eleven
people were sickened by the germs, and one of them died.
1951-1960: University of Pennsylvania under contract with U.S. Army
conducts psychopharmacological experiments on hundreds of
1952-1974: University of Pennsylvania dermatologist Dr. Albert
Kligman conducts skin product experiments by the hundreds at
Holmesburg Prison; “All I saw before me,” he has said about his
first visit to the prison, “were acres of skin.”
1952: Henry Blauer injected with a fatal dose of mescaline at New
York State Psychiatric Institute of Columbia University. U.S.
Department of Defense, the sponsor, conspired to conceal evidence
for 23 years.
1953 Newborn Daniel Burton rendered blind at Brooklyn Doctor’s
Hospital due to high oxygen study on RLF.
1953-1957: Oak Ridge-sponsored injection of uranium into eleven
patients at Massachusetts General Hospital in Boston.
1953-1960: CIA brainwashing experiments with LSD at eighty
institutions on hundreds of subjects in a project code named “MK-
1953-1970: U.S. Army experiments with LSD on soldiers at Fort
1954-1974: U.S. Army study of 2,300 Seventh-Day Adventist soldiers
in 157 experiments code named “Operation Whitecoat.”
1950s – 1972: Mentally disabled children at Willowbrook School (NY)
were deliberately infected with hepatitis in an attempt to find a
vaccine. Participation in the study was a condition for admission
1956: Dr. Albert Sabin tests experimental polio vaccine on 133
prisoners in Ohio.
1958-1962: Spread of radioactive materials over Inupiat land in
Point Hope, Alaska in Atomic Energy Commission field study code
named “Project Chariot.”
1962: Thalidomide withdrawn from the market after thousands of
birth deformities blamed in part on misleading results of animal
studies; the FDA thereafter requires three phases of human clinical
trials before a drug can be approved for the market.
1962 to 1966, a total of 33 pharmaceutical companies tested 153
experimental drugs at Holmesburg prison (PA) alone.
1962-1980 Pharmaceutical companies conduct Phase I safety testing
of drugs almost exclusively on prisoners for small cash payments.
1962: Injection of live cancer cells into 22 elderly patients at
Jewish Chronic Disease Hospital in Brooklyn. Administration covered
up, NYS licensing board placed the principal investigator on
probation for one year. Two years later, American Cancer Society
elected him Vice President.
1962: Stanley Milgram conducts obedience research at Yale
1963: NIH supported researcher transplants chimpanzee kidney into
human in failed experiment.
1963-1973: Dr. Carl Heller, a leading endocrinologist, conducts
testicular irradiation experiments on prisoners in Oregon and
Washington giving them $5 a month and $100 when they receive a
vasectomy at the end of the trial.
1964: World Medical Association adopts Helsinki Declaration,
asserting “The interests of science and society should ever take
precedence over the well being of the subject.”
1965-1966: University of Pennsylvania under contract with Dow
Chemical conducts dioxin experiments on prisoners at Holmesburg.
1966: Henry Beecher’s article “Ethics and Clinical Research” in New
England Journal of Medicine.
1966: U.S. Army introduces bacillus globigii into New York subway
tunnels in field study.
1966: NIH Office for Protection of Research Subjects (“OPRR”)
created and issues Policies for the Protection of Human Subjects
calling for establishment of independent review bodies later known
as Institutional Review Boards.
1967: British physician M.H. Pappworth publishes “Human Guinea
Pigs,” advising “No doctor has the right to choose martyrs for
science or for the general good.”
1969: Judge Sam Steinfield’s eloquent dissent in Strunk v. Strunk,
445 S.W.2d 145, the first judicial suggestion that the Nuremberg
Code should influence American jurisprudence.
1969. Milledgeville Georgia, investigational drugs tested on
mentally disabled children. No institutional approval.
1969: San Antonio Contraceptive Study conducted on 70 poor Mexican-
American women. Half received oral contraceptives the other
placebo. No informed consent.
1973 Ad Hoc Advisory Panel issues Final Report of Tuskegee Syphilis
Study, concluding “Society can no longer afford to leave the
balancing of individual rights against scientific progress to the
1974: National Research Act establishes National Commission for the
Protection of Human subjects and requires Public Health Service to
promulgate regulations for the protection of human subjects.
1975: The Department of Health, Education and Welfare (DHEW) raised
NIH’s 1966 Policies for the Protection of Human subjects to
regulatory status. Title 45 of the Code of Federal Regulations,
known as “The Common Rule,” requires the appointment and
utilization of institutional review boards (IRBs).
1976: National Urban League holds National Conference on Human
Experimentation, announcing “We don’t want to kill science but we
don’t want science to kill, mangle and abuse us.”
1978: Experimental Hepatitis B vaccine trials, conducted by the
CDC, begin in New York, Los Angeles and San Francisco. Ads for
research subjects specifically ask for promiscuous homosexual men.
1979: National Commission issues Belmont Report setting forth three
basic ethical principles: respect for persons, beneficence, and
1980: The FDA promulgates 21 CFR 50.44 prohibiting use of prisoners
as subjects in clinical trials shifting phase I testing by
pharmaceutical companies to non-prison population.
1981: Leonard Whitlock suffers permanent brain damage after deep
diving experiment at Duke University.
1986: Congressional subcommittee holds one-day hearing in
Washington, called by Rep. Pat Williams of Montana, aimed at
determining whether U.S. prisoners of war in Manchuria were victims
of germ-warfare experimentation. Hearing is inconclusive.
1981-1996: Protocol 126 at Fred Hutchinson Cancer Center in
1987: Supreme Court decision in United States v. Stanley, 483 U.S.
669, holding soldier given LSD without his consent could not sue
U.S. Army for damages.
1987:” L-dopa challenge and relapse” experiment conducted on 28
U.S. veterans who were subjected to psychotic relapse for study
purposes at the Bronx VA.
1990: The FDA grants Department of Defense waiver of Nuremberg Code
for use of unapproved drugs and vaccines in Desert Shield.
1991: World Health Organization announces CIOMS Guidelines which
set forth four ethical principles: respect for persons,
beneficence, non-maleficence and justice.
1991: Tony LaMadrid commits suicide after participating in study on
relapse of schizophrenics withdrawn from medication at UCLA.
1993: Kathryn Hamilton dies 44 days after participating in breast
cancer experiment at Fred Hutchinson Cancer Center in Seattle.
1994. The Albuquerque Tribune publicizes 1940s experiments
involving plutonium injection of human research subjects and secret
radiation experiments. Indigent patients and mentally retarded
children were deceived about the nature of their treatment.
1994. President Clinton appoints the Advisory Commission on Human
Radiation Experiments (ACHRE) The ACHRE Report
1995. U.S. Department of Energy (DOE) published Human Radiation
Experiments, listing 150 plus an additional 275 radiation
experiments conducted by DOE and the Atomic Energy Commission,
during the 1940s-1970s.
1995: 19-year-old University of Rochester student Nicole Wan dies
after being paid $150 to participate in MIT-sponsored experiment to
test airborne pollutant chemicals.
1995. President Clinton appoints the National Bioethics Advisory
1995: NYS Supreme Court rules (TD v NYS Office of Mental Health)
against the state’s policy of conducting non-therapeutic
experiments on mentally incapacitated persons – including children -
without informed consent. Justice Edward Greenfield ruled that
parents have no authority to volunteer their children: “Parents may
be free to make martyrs of themselves, but it does not follow that
they may make martyrs of their children.”
1995: Thirty-four healthy, previously non-aggressive New York City
minority children, boys aged 6 to 11 years old, were exposed to
fenfluramine in a non-therapeutic experiment at the New York State
Psychiatric Institute. The children were exposed to this neurotoxic
drug to record their neurochemical response in an effort to prove a
speculative theory linking aggression to a biological marker.
1996. Cleveland Plain Dealer investigative report series, ‘Drug
Trials: Do People Know the Truth About Experiments,’ December 15 to
18, 1996. The Plain-Dealer found: of the “4,154 FDA inspections of
researchers testing new drugs on people [since 1977]… more than
half the researchers were cited by FDA inspectors for failing to
clearly disclose the experimental nature of their work.”
1996: Yale University researchers publish findings of experiment
that subjected 18 stable schizophrenia patients to psychotic
relapse in an amphetamine provocation experiment at West Haven VA.
1997. President Clinton issues a formal apology to the subjects of
the Tuskegee syphilis experiments. NBAC continues investigation
into genetics, consent, privacy, and research on persons with
1997. Researchers at the University of Cincinnati publish findings
of experiment attempting to create a “psychosis model” on human
beings at the Cincinnati VA. Sixteen patients, experiencing a first
episode schizophrenia, were subjected to repeated provocation with
amphetamine. The stated purpose was to produce “behavioral
sensitization. This process serves as a model for the development
of psychosis, but has been little studied in humans. Symptoms, such
as severity of psychosis and eye-blink rates, were measured hourly
for 5 hours.”
1997. U.S. government sponsored placebo-controlled experiment
withholds treatment from HIV infected, pregnant African women. NY
Times, Sept. 18.
1997. Victims of unethical research at major U.S. medical centers -
including the NIMH – testify before the National Bioethics Advisory
Commission, Sept. 18.
1997. FDA Modernization Act gives pharmaceutical companies a huge
financial incentive – a 6 month patent exclusivity extension – if
they conduct drug tests on children. The incentive can yield $900
1998. National Bioethics Advisory Commission (NBAC) Report.
Research Involving Subjects with Mental Disorders That May Affect
Decision-making Capacity. November 12, 1998
1998: The Japanese government has never formally apologized for
Unit 731’s activities, and did not even admit to its existence
until August 1998, when the Supreme Court ruled that the existence
of the unit was accepted in academic circles.
1998. Complaint filed with OPRR about experiments that exposed non-
violent children in New York City to fenfluramine to find a
predisposition to violence.
1998: Boston Globe (four part) series, “Doing Harm: Research on the
Mentally Ill” shed light on the mistreatment and exploitation of
schizophrenia patients who have been subjected to relapse producing
procedures in unethical experiments.
1999: Nine month-old Gage Stevens dies at Children’s Hospital in
Pittsburgh during participation in Propulsid clinical trial for
infant acid reflux.
1999: 18-year-old Jesse Gelsinger dies after being injected with 37
trillion particles of adenovirus in gene therapy experiment at
University of Pennsylvania.
1999: Director of National Institute of Mental Health suspends 29
clinical trials that failed to meet either ethical or scientific
2000: University of Oklahoma melanoma trial halted for failure to
follow government regulations and protocol.
2000: OPRR becomes Office of Human Research Protection (“OHRP”) and
made part of the Department of Health and Human Services.
2000: President Clinton implement the Energy Employees Occupational
Illness Compensation Act of 2000, which authorized compensation for
thousands of Department of Energy workers who sacrificed their
health in building the nation’s nuclear defenses.
2000: The Washington Post (6 part) series, “Body Hunters” exposes
unethical exploitation in experiments conducted by U.S.
investigators in underdeveloped countries. Part 4 dealt with U.S.
government funded, genetic experiments conducted by Harvard
University in rural China.
2001: A biotech company in Pennsylvania asks the FDA for permission
to conduct placebo trials on infants in Latin America born with
serious lung disease though such tests would be illegal in U.S.
2001: Ellen Roche, a healthy 27-year old volunteer, dies in
challenge study at Johns Hopkins University in Baltimore, Maryland.
2001: April 4, Elaine Holden-Able, a healthy retired nurse,
consumed a glass of orange juice that had been mixed with a dietary
supplement for the sake of medical research. This Case Western
University Alzheimer’s experiment, financed by the tobacco
industry, wound up killing her in what was called a “tragic human
error.” Federal Office of Human Research Protections did not
interview hospital staff, mostly accepted hospital’s internal
report, imposed no penalty, and closed the case and did not mention
the death in its letter of determination.
2001: Maryland Court of Appeals renders a landmark decision
affirming “best interest of the individual child” as a standard for
medical research involving children. The Court unequivocally
prohibited non-therapeutic experimentation on children. (Higgins
and Grimes v. Kennedy Krieger Institute). The case involved
exposure of babies and small children to lead poisoning in EPA
A History of US Secret Human Experimentation
2000 – Health News Network
from Rense Website
1931 Dr. Cornelius Rhoads, under the auspices of the Rockefeller
Institute for Medical Investigations, infects human subjects with
cancer cells. He later goes on to establish the U.S. Army
Biological Warfare facilities in Maryland, Utah, and Panama, and is
named to the U.S. Atomic Energy Commission. While there, he begins
a series of radiation exposure experiments on American soldiers and
civilian hospital patients.
1932 The Tuskegee Syphilis Study begins. 200 black men diagnosed
with syphilis are never told of their illness, are denied
treatment, and instead are used as human guinea pigs in order to
follow the progression and symptoms of the disease. They all
subsequently die from syphilis, their families never told that they
could have been treated.
1935 The Pellagra Incident. After millions of individuals die from
Pellagra over a span of two decades, the U.S. Public Health Service
finally acts to stem the disease. The director of the agency admits
it had known for at least 20 years that Pellagra is caused by a
niacin deficiency but failed to act since most of the deaths
occurred within poverty-stricken black populations.
1940 Four hundred prisoners in Chicago are infected with Malaria in
order to study the effects of new and experimental drugs to combat
the disease. Nazi doctors later on trial at Nuremberg cite this
American study to defend their own actions during the Holocaust.
1942 Chemical Warfare Services begins mustard gas experiments on
approximately 4,000 servicemen. The experiments continue until 1945
and made use of Seventh Day Adventists who chose to become human
guinea pigs rather than serve on active duty.
1943 In response to Japan’s full-scale germ warfare program, the
U.S. begins research on biological weapons at Fort Detrick, MD.
1944 U.S. Navy uses human subjects to test gas masks and clothing.
Individuals were locked in a gas chamber and exposed to mustard gas
1945 Project Paperclip is initiated. The U.S. State Department,
Army intelligence, and the CIA recruit Nazi scientists and offer
them immunity and secret identities in exchange for work on top
secret government projects in the United States.
1945 “Program F” is implemented by the U.S. Atomic Energy
Commission (AEC). This is the most extensive U.S. study of the
health effects of fluoride, which was the key chemical component in
atomic bomb production. One of the most toxic chemicals known to
man, fluoride, it is found, causes marked adverse effects to the
central nervous system but much of the information is squelched in
the name of national security because of fear that lawsuits would
undermine full-scale production of atomic bombs.
1946 Patients in VA hospitals are used as guinea pigs for medical
experiments. In order to allay suspicions, the order is given to
change the word “experiments” to “investigations” or “observations”
whenever reporting a medical study performed in one of the nation’s
1947 Colonel E.E. Kirkpatrick of the U.S. Atomic Energy Commission
issues a secret document (Document 07075001, January 8, 1947)
stating that the agency will begin administering intravenous doses
of radioactive substances to human subjects.
1947 The CIA begins its study of LSD as a potential weapon for use
by American intelligence. Human subjects (both civilian and
military) are used with and without their knowledge.
1950 Department of Defense begins plans to detonate nuclear weapons
in desert areas and monitor downwind residents for medical problems
and mortality rates.
1950 I n an experiment to determine how susceptible an American
city would be to biological attack, the U.S. Navy sprays a cloud of
bacteria from ships over San Francisco. Monitoring devices are
situated throughout the city in order to test the extent of
infection. Many residents become ill with pneumonia-like symptoms.
1951 Department of Defense begins open air tests using disease-
producing bacteria and viruses. Tests last through 1969 and there
is concern that people in the surrounding areas have been exposed.
1953 U.S. military releases clouds of zinc cadmium sulfide gas over
Winnipeg, St. Louis, Minneapolis, Fort Wayne, the Monocacy River
Valley in Maryland, and Leesburg, Virginia. Their intent is to
determine how efficiently they could disperse chemical agents.
1953 Joint Army-Navy-CIA experiments are conducted in which tens of
thousands of people in New York and San Francisco are exposed to
the airborne germs Serratia marcescens and Bacillus glogigii.
1953 CIA initiates Project MKULTRA. This is an eleven year research
program designed to produce and test drugs and biological agents
that would be used for mind control and behavior modification. Six
of the subprojects involved testing the agents on unwitting human
1955 The CIA, in an experiment to test its ability to infect human
populations with biological agents, releases a bacteria withdrawn
from the Army’s biological warfare arsenal over Tampa Bay, Fl.
1955 Army Chemical Corps continues LSD research, studying its
potential use as a chemical incapacitating agent. More than 1,000
Americans participate in the tests, which continue until 1958.
1956 U.S. military releases mosquitoes infected with Yellow Fever
over Savannah, Ga and Avon Park, Fl. Following each test, Army
agents posing as public health officials test victims for effects.
1958 LSD is tested on 95 volunteers at the Army’s Chemical Warfare
Laboratories for its effect on intelligence.
1960 The Army Assistant Chief-of-Staff for Intelligence (ACSI)
authorizes field testing of LSD in Europe and the Far East. Testing
of the European population is code named Project THIRD CHANCE;
testing of the Asian population is code named Project DERBY HAT.
1965 CIA and Department of Defense begin Project MKSEARCH, a
program to develop a capability to manipulate human behavior
through the use of mind-altering drugs.
1965 Prisoners at the Holmesburg State Prison in Philadelphia are
subjected to dioxin, the highly toxic chemical component of Agent
Orange used in Viet Nam. The men are later studied for development
of cancer, which indicates that Agent Orange had been a suspected
carcinogen all along.
1966 CIA initiates Project MKOFTEN, a program to test the
toxicological effects of certain drugs on humans and animals.
1966 U.S. Army dispenses Bacillus subtilis variant niger throughout
the New York City subway system. More than a million civilians are
exposed when army scientists drop lightbulbs filled with the
bacteria onto ventilation grates.
1967 CIA and Department of Defense implement Project MKNAOMI,
successor to MKULTRA and designed to maintain, stockpile and test
biological and chemical weapons.
1968 CIA experiments with the possibility of poisoning drinking
water by injecting chemicals into the water supply of the FDA in
1969 Dr. Robert MacMahan of the Department of Defense requests from
congress $10 million to develop, within 5 to 10 years, a synthetic
biological agent to which no natural immunity exists.
1970 Funding for the synthetic biological agent is obtained under
H.R. 15090. The project, under the supervision of the CIA, is
carried out by the Special Operations Division at Fort Detrick, the
army’s top secret biological weapons facility. Speculation is
raised that molecular biology techniques are used to produce AIDS-
1970 United States intensifies its development of “ethnic weapons”
(Military Review, Nov., 1970), designed to selectively target and
eliminate specific ethnic groups who are susceptible due to genetic
differences and variations in DNA.
1975 The virus section of Fort Detrick’s Center for Biological
Warfare Research is renamed the Fredrick Cancer Research Facilities
and placed under the supervision of the National Cancer Institute
(NCI) . It is here that a special virus cancer program is initiated
by the U.S. Navy, purportedly to develop cancer-causing viruses. It
is also here that retro-virologists isolate a virus to which no
immunity exists. It is later named HTLV (Human T-cell Leukemia
1977 Senate hearings on Health and Scientific Research confirm that
239 populated areas had been contaminated with biological agents
between 1949 and 1969. Some of the areas included San Francisco,
Washington, D.C., Key West, Panama City, Minneapolis, and St.
1978 Experimental Hepatitis B vaccine trials, conducted by the CDC,
begin in New York, Los Angeles and San Francisco. Ads for research
subjects specifically ask for promiscuous homosexual men.
1981 First cases of AIDS are confirmed in homosexual men in New
York, Los Angeles and San Francisco, triggering speculation that
AIDS may have been introduced via the Hepatitis B vaccine
1985 According to the journal Science (227:173-177), HTLV and
VISNA, a fatal sheep virus, are very similar, indicating a close
taxonomic and evolutionary relationship.
1986 According to the Proceedings of the National Academy of
Sciences (83:4007-4011), HIV and VISNA are highly similar and share
all structural elements, except for a small segment which is nearly
identical to HTLV. This leads to speculation that HTLV and VISNA
may have been linked to produce a new retrovirus to which no
natural immunity exists.
1986 A report to Congress reveals that the U.S. Government’s
current generation of biological agents includes: modified viruses,
naturally occurring toxins, and agents that are altered through
genetic engineering to change immunological character and prevent
treatment by all existing vaccines.
1987 Department of Defense admits that, despite a treaty banning
research and development of biological agents, it continues to
operate research facilities at 127 facilities and universities
around the nation.
1990 More than 1500 six-month old black and Hispanic babies in Los
Angeles are given an “experimental” measles vaccine that had never
been licensed for use in the United States. CDC later admits that
parents were never informed that the vaccine being injected to
their children was experimental.
1994 With a technique called “gene tracking,” Dr. Garth Nicolson at
the MD Anderson Cancer Center in Houston, TX discovers that many
returning Desert Storm veterans are infected with an altered strain
of Mycoplasma incognitus, a microbe commonly used in the production
of biological weapons. Incorporated into its molecular structure is
40 percent of the HIV protein coat, indicating that it had been man-
1994 Senator John D. Rockefeller issues a report revealing that for
at least 50 years the Department of Defense has used hundreds of
thousands of military personnel in human experiments and for
intentional exposure to dangerous substances. Materials included
mustard and nerve gas, ionizing radiation, psycho-chemicals,
hallucinogens, and drugs used during the Gulf War .
1995 U.S. Government admits that it had offered Japanese war
criminals and scientists who had performed human medical
experiments salaries and immunity from prosecution in exchange for
data on biological warfare research.
1995 Dr. Garth Nicolson, uncovers evidence that the biological
agents used during the Gulf War had been manufactured in Houston,
TX and Boca Raton, Fl and tested on prisoners in the Texas
Department of Corrections.
1996 Department of Defense admits that Desert Storm soldiers were
exposed to chemical agents.
1997 Eighty-eight members of Congress sign a letter demanding an
investigation into bio-weapons use & Gulf War Syndrome.
Human Experimentation Before the Nazi Era and After
by Roberta Kalechofsky, PhD.
from MicahBooks Website
“First animals, then orphans, then the mentally retarded.”
David J. Rothman
Strangers At The Bedside.
In 1907, Dr. Albert Leffingwell concluded his booklet, Illustration
of Human Vivisection, with this chilling prophecy:
“At the beginning of a new century we are confronted by great
problems. One of these is human vivisection in the name of
scientific research. We appeal, then, to the medical press of
America to beak that unfortunate silence which seems to justify or,
at least, to condone it.
Now and henceforth, will it not join us in condemning every such
vivisector of little children, every such experimenter upon human
beings? We make this appeal to it in the name of Justice and
Humanity and for the sake of millions yet unborn.”
The intellectual and philosophical rationalizations, as well as
much of the practice of human experimentation, was well advanced by
the end of the nineteenth century, and presents a continuing danger
to human rights today, particularly when faced with the stimulus of
crisis and war.
The history of human experimentation in the West is usefully
divided into two eras: before the Nazi era and after. Human
experimentation neither arose with the Nazis, nor ended with them.
But the Nazi era, to paraphrase Samuel Johnson’s famous statement
that “Nothing concentrates a man’s thoughts so much as the
knowledge that he is to be hanged on the morrow” – the Nazi era
concentrated our thoughts about human experimentation and, to some
extent, halted its momentum. But it did not end the practice of
what Dr. Leffingwell called at the beginning of the century, “the
Vivisection was practiced in the Roman era on gladiators and
slaves. But this vivisection, monstrous to the living victim, was
The real history of vivisection begins in the nineteenth century
with the rise of the experimental method in science, and
subsequently in medicine. It arises from and accompanies animal
experimentation which, with the work of Claude Bernard in the mid-
nineteenth century, became the standard methodology in modern
medicine. As soon as animal vivisection became standard practice,
the question arose about experimental research on human beings.
Animal researchers recognized that an inescapable problem had been
created: the only way animal research could really be validated for
human medical problems was to finally conduct the experiment on
human beings, for there is no assurance from animal research itself
that a given drug would be valid for human application.
A famous example is the fact that aspirin kills rabbits, and if
researchers had been guided in their use of aspirins by this
laboratory research, human beings would have been denied a valuable
Michael Krater summarizes the process in his book, Doctors Under
“One of the prerequisites that turned into a sort of fetish of this
exact-scientific attitude was the experiment–it, too, a child of
rationalization in the past century. At the universities, the
theories had to be validated by experiments.
It was unquestioned that advances in medicine (as in natural
science) could be achieved only through the inductive method of
formulating a hypothesis and testing it, by subjecting it to
revision and verification in a controlled series of empirical
However, Michael Krater’s further statement is only partially true:
“Throughout the 1920s and well into the Third Reich, German medical
scientists were ruled by a consensus that as desirable as human
experiments were, for moral reasons animals had to suffice as
objects of empirical experimentation.”
That was the desideratum, but by the turn of the century
experimentation on human beings was on its way to becoming
respectable. The famous chemist, E.E. Slosson wrote on Dec.
12th,1895, in the New York Independent,
“A human life is nothing compared with a new fact in science….the
aim of science is the advancement of human knowledge at any
sacrifice of human life….We do not know of any higher use we can
put a man to.”
Professor Starling of University College, London, openly declared
in 1906 to Britain’s Parliament at its investigation into
vivisection practices, “The last experiment must be on man.”
What animal research does is to provide a seemingly safety net and
guidelines for procedure with human beings. Sometimes this safety
net works, sometimes it doesn’t; sometimes it’s misleading, but it
is standard procedure, so that animal and human experimentation are
two sides of the same coin.
An article in The New Republic (April 26 and May 2, 1999) by Jerome
Groopman, quixotically entitled “Merciful Medicine,” describes the
system very well:
“After extensive testing in small animals, drugs are tested for
toxicity in human beings during what is known as Phase I trials.
This first phase is designed to gauge the side effects of the
drugs, usually on groups of three or four people that get very low
doses of the drug, followed by groups that receive successively
higher doses until intolerable toxicity is reached [like LD50 drug
testing in animals].
There is no expectation of clinical benefit in this first phase.
Furthermore, Phase I studies take virtually all comers.”
Groopman goes on to describe Phase II and Phase III of human
experimentation, in an article intended as a plea to allow those
who wish to to volunteer for human experimentation.
It was only a matter of time until medicine would arrive at this
point where the need for volunteers for human experimentation would
become inescapable and would mandate a “merciful plea.”
As Michael Krater describes the escalation under Nazi Germany,
“Because animal experimentation was known to be a poor substitute
for experiments on humans, for only analogous inferences could be
drawn, the crossover to human experimentation during the war became
a logical consequence of prior practices that had been fettered.”
The evolution from animal experimentation to human experimentation
is a logical consequence of laws governing the experimental
process, whether in Nazi Germany, or elsewhere, and not the result
of preferring humans to animals.
As Krater writes,
“…the often-encountered theory that Nazis spurned human life in
preference for that of animals, in particular house pets, is
without basis in fact–non-suspect societies love pets also.”
The Weimar law passed in 1931 with respect to animal and human
experimentation required that German and, subsequently Nazi,
doctors must first conduct their experimental procedures on animals
before proceeding to human beings.
This law was never abrogated in Nazi Germany and is similar to laws
in the United States today. All experiments with human beings are
and were first conducted on animals, and experimenters in and out
of Nazi Germany had to validate this procedure.
Thus, when Dr. Karl Rascher made his request on May 15, 1941 to the
Reich Leader Himmler, “for two or three professional criminals,”
for high altitude test experiments of eighteen thousand meters, he
pointed out that this experiment had been tried on monkeys, but
that monkeys outlived their usefulness at 12,000 meters, and he now
had to proceed to the use of humans. Research on animals does not
protect human beings from becoming experimental guinea pigs.
The literature of the nineteenth century illustrates a continuing
increase in the use of human beings for medical experiments,
beginning in the last two decades of that century. With the rise of
the germ theory and of the pharmaceutical companies, testing on
both animals and humans proliferated at dizzying speeds.
In her book, Subjected to Science: Human Experimentation in America
Before the Second World War, Susan Lederer writes:
“The science of bacteriology engendered substantial experimentation
on human beings and animals….Isolating and identifying a disease
germ under the microscope was the first step. After growing the
microorganism in a pure culture, the physicians needed to use the
germ to produce the disease in a healthy organism.
“The use of human beings to confirm that a microbe caused a
particular disease to demonstrate the mode of transmission was a
harsh legacy of the germ theory of disease. Unable to find a
suitable animal model in which to study the disease, physicians
turned to human subjects. Before the discovery that monkeys could
be infected with syphilis and gonorrhea, the search for microbes of
venereal disease prompted more than forty reports of experiments in
which individuals were inoculated with the suspected germs of
gonorrhea and syphilis.
In 1895 New York pediatrician Henry Heiman… described the
successful gonorrheal infection of a 4-year-old boy (“an idiot with
chronic epilepsy”), a 16-year-old boy (an “idiot”) and a 26-year-
old man in the final stages of tuberculosis”
This information is in the medical journals of its time, The
American Journal of Syphilis of 1943, and the Journal Cut. Genito-
Urinary Diseases of 1895.
It is germaine to the problem of informed consent that two of the
subjects are described as “idiots,” therefore presumably incapable
of giving informed consent. Who then gave it for them, and should
others have the right to give such consent for others? Should a
parent in need of money have the right to give consent for a child
to be experimented upon? Would this be considered “selling” a child
to science. These are problems that degrade the integrity of the
concept of informed consent.
Usually the human beings used for experimental purposes were–and
are– the disenfranchised, populations of prisoners, orphans, the
mentally retarded, charity patients of all kinds. Dr. Leffingwell’s
study uncovered decades of experiments on human beings in charity
wards and on children in orphan asylums. None of these experiments
were as horrific as those conducted by the Nazis, but they were
quite serious enough.
Leffingwell documented experiments by Dr. Sydney Ringer of
University Hospital of London, who experimented with poisons, such
as overdoses of salicin, nitrate of sodium, gelseminum and other
toxic agents, often on children under the age of ten. Due to the
experiments, the children suffered from severe headaches, vomiting,
twitching of limbs, burning sensations in the eyes, and other
Dr. Leffingwell commented:
“A distressing feature of many of these experiments is the fact
that the men and women upon whom they were performed were not only
ignorant, but under constraint. In this horrible case certain
patients in the hospitals were not merely poisoned once, but were
obliged ‘on compulsion’ to undergo the convulsive paroxysms and all
the other agonizing symptoms a second time”
Dr. Ringer’s experiments were published in a book called Handbook
of Therapeutics. Far from receiving criticism for his experiments
on children, Dr. Ringer’s book went through eight editions and was
regarded as a respectable medical book.
In 1906, the British Parliament conducted The Second Royal
Commission into Vivisection Practices. H.H. Levy, the Honorable
Secretary of the Personal Rights Association, told the Commission,
“These experiments are not confined to animals and never have been
confined to animals; they have always been performed on human
beings, as well as on animals.”
Indeed, the Commission uncovered decades of evidence of routine
Some of these experiments were published in 1949 in E. Westacot’s
book, A Century of Vivisection and Anti-Vivisection. Westacott’s
book describes the experiments of Professor Neisser of Vienna who,
on March 29, 1899, reported in the Medical Press of Vienna, how he
had inoculated eight healthy children with syphilis.
Three of the children developed symptoms of the disease, and a
fourth suffered later in life from a cerebral tumor. While
Professor Neisser was condemned and fined by the disciplinary court
of Breslau, he was rewarded by the West London Chirurgical Society
in England in 1911, with the Cavendish Gold Medal for his research,
and a reception was held in his honor. Apart from the Nazi doctors,
it is hard to find a single doctor who was seriously punished for
human experimentation, and who was not in fact professionally
In the United States, in 1913, the Pennsylvania House of
Representatives recorded that 146 children had been inoculated with
the syphilis virus, “through the courtesy of the various hospitals”
and that 15 children in St. Vincent’s House in Philadelphia had had
their eyes tested with tuberculin. Several of these children became
The experimenters were not punished. Moreover, this case further
illustrates that the doctrine of “informed consent” proves to be
practically inoperable in the case of institutionalized people,
particularly children, because in most of these circumstances it is
the institution’s supervisor who is responsible for giving
“informed consent” and usually gives it.
Experimentation on human beings was not confined to bacteriological
research. J. Marion Sims, the “father of gynecology” performed
experimental surgery, before the days of anesthesia, on several
slaves, and performed thirty-four experimental operations on a
single black female slave for a prolapsed uterus.
One of the most famous cases in human experimentation involves an
Irish servant girl, Mary Rafferty, who entered Good Samaritan
Hospital in Cincinnati in 1874, with an ulcerated tumor on the side
of her head, which had been caused by a bad burn.
Mary Rafferty’s case demonstrates the characteristics usually
inherent in cases of human experimentation: the ambiguity involved
in determining whether informed consent had been obtained, the
shadow land between experimentation and therapy, the fact that only
the attending physicians really know the truth of what occurred.
Her physicians diagnosed the ulcer on her scalp as cancerous and
apparently attempted to treat her condition surgically. When they
believed that her situation could not be remedied, they proceeded
to experiment on her. One of Mary’s physicians, Roberts Bartholow
was interested in experiments Dr. David Ferrier had made with dogs
using electric shock to determine the localization of epilepsy.
The experiments with Mary are described as follows:
“When the needle entered the brain substance, she complained of
acute pain in the neck. In order to develop more decided reaction,
the strength of the current was increased by drawing out the wooden
cylinder one inch. When communication was made with the needles,
her countenance exhibited great distress, and she began to cry.
Very soon, the left hand was extended as if in the act of taking
hold of some object in front of her; the arm presently was agitated
with chronic spasm; her eyes became fixed with pupils widely
dilated; her lips were blue, and she frothed at the mouth; her
breathing became stertorus; she lost consciousness and was
violently convulsed on the left side.
The convulsion lasted five minutes, and was succeeded by a coma.
She returned to consciousness in twenty minutes from the beginning
of the attack, and complained of some weakness and vertigo.”
The Mary Rafferty Case illustrates a persistent pattern in issues
of human experimentation: she died a few days later, and her death
certificate stated that she died from cancer.
There was criticism of Dr. Bartholow’s experiment: it was condemned
by the American Medical Association, but Dr. Bartholow did not
suffer professionally. Indeed, he advanced professionally. Scandal
arises, then scandal subsides, and the researcher is rewarded.
The second issue is that while Dr. Bartholow conceded that his
experiment had perhaps gone too far, he asserted emphatically that
Mary had given informed consent and that his experiments did not
cause her death. But even if the experiments did not cause her
death, she was entitled to die without unnecessary pain. The
argument that “the patient was going to die anyway” is a gross
argument, and one that was used by the Nazi doctors. Bad enough the
patient is going to die; it is no excuse for the patient to be
tortured while dying.
We do not permit condemned prisoners to be tortured on the excuse
that they’re going to die anyway. (However, there are constant
proposals from research medicine that prisoners on death row be
used for experimental purposes. Would such “experiments” constitute
torture or not?)
The third issue is that of Mary Rafferty’s consent. Dr. Bartholow
argued that she was not feeble-minded and understood his questions
to her. There is a contradiction in this argument. If Mary Rafferty
really understood Dr. Bartholow’s description of what he was about
to do, common sense tells us she would not have consented. This is
the crux of the issue with most “informed consent” problems.
Examination of particular experiments invariably suggests that the
patient did not understand what he or she was consenting to.
“Informed consent” proves to be a treacherous deception in many
At a conference on “The Nazi Doctors and the Nuremberg Code” at
Boston University in 1989, Dr. Arthur Caplan stated that the
principle of informed consent, which is the cornerstone of
protection for human rights in a medical context, is now so eroded
that it has evolved into “protection of the researcher” and a
license to experiment.
“Informed consent” does not respond to the more common types of
experimentation on human beings, where the area between therapy and
experimentation is blurred, and where it is difficult to pass
judgment on medical procedure. An article in The New York Times
(Nov., 1996) by Gina Kolata, demonstrates the ubiquity of the
problem. The Food and Drug Administration gave permission to lift
the requirement of informed consent for patients who have been
brought into a hospital, suffering from a head injury which has
rendered them unconscious, and who have no identification. Who is
to give consent in this case?
Though this step marks a grave departure from the Nuremberg Code,
it has aroused little public reaction. Of course, the argument in
defense of the lifting of this ban is the necessity to treat a
patient, even experimentally, who cannot speak for him or herself.
But how many people are wandering about without any identification?
The population of “unidentifiable” people is immediately
identifiable: the homeless and probably illegal immigrants.
Even with alert and identifiable patients, as Jay Katz observed at
the Boston University Conference, informed consent is meaningless
unless the patient is educated and medically very knowledgeable,
but most sick people, as Dr. Katz pointed out, are not in a
position to argue with their physicians: they are “coerced by
disease,” by pain, by fear of death, and often by ignorance.
In real practice–not theoretical practice – the concept of
“informed consent” has led to the duplicitous practice of what
Bradford H. Gray calls in his book, Human Subjects in Medical
Experimentations, “the engineering of consent.”
His study unsurprisingly reveals that “informed consent” is often a
mirage, often coerced from frightened people who are in too much
pain and confusion to withstand a request from a doctor.
In the introduction to Gray’s book, Bernard Barber exposes the myth
of medical experimental outrages as the aberration of a “few bad
“There is a mistaken belief held by some medical researchers, and
even by those who deplore the defects in present practices in this
field, that the shortcomings and scandals that occur can be traced
to a handful of individuals who lack the requisite personal
qualities. They recommend that ‘the honest, conscientious,
compassionate physician’ be the ultimate safeguard of the human
research subject. But Gray’s book shows that ‘honest,
conscientious, compassionate’ physicians have been led into bad
practice by a bad system.”
Experimentation on human beings is not the work of a few aberrant
doctors; it is systemic, because it is the system by which modern
western medicine works.
Exposés of outrageous experiments, such as Dr. Henry Beecher’s
book, Research and The Individual, written in 1966, often endorse
research on human beings. Dr. Beecher wrote,
“The well-being, the health, even the actual or potential life of
all human beings, born or unborn, depend upon the continuing
experimentation in man. Proceed it must; proceed it will. ‘The
proper study of mankind is man.’”
The Nuremberg trials brought to light the horrors of medical
experimentation on human beings, and tried to articulate a
restraining formula by stressing the concept of “informed consent,”
but the trials also recognized that
“Medical science cannot, unless it is to be brought to a
standstill, dispense with the application in suitable cases of new
remedies and procedures not yet fully tested. Nor can it do
entirely without scientific experiment on human beings itself.”
In 1931, Germany already possessed a good bioethical code which
contained almost all the points of the Nuremberg Code.
Yet it failed to curb the rapacious desire to experiment. By the
time of the Nazi experiments, the legal procedure and conduct of
experimentation with human beings had been laid down in Germany,
the United States and England. Experimentation on human beings was
not condemned. What was condemned in Germany was the political and
racial uses of human experimentation, and its excesses.
The defense of the Nazi doctors rested on the argument that their
procedure was standard Western medical practice, and they submitted
cartons of documentation of experiments on human beings in Western
hospitals to prove their case, including an exhaustive volume,
entitled, Experiments on Human Beings in World Literature, by Dr.
Erich H. Hahlbach, which describes such experiments as those
conducted on “eight hundred convicts from three American prisons”
artificially infected with malaria, who presumably volunteered for
this experiment, prisoners in Turkey sentenced to death, infected
with typhus, prisoners sentenced to death infected with plague,
The defense pointed out that,
“Out of fifty-three printed sources quoted, seventeen state that
the subjects consented. In thirty-six the matter was not mentioned
in any way and in several of these cases it appeared that the
subjects might not have presented themselves willingly.”
The defense’s argument was that experimentation with human beings
had been accepted medical procedure.
The question, they asked, is whether “medical experimentation can
be considered a crime.” The prosecution did not argue this, but
condemned the experiments because they had been used for political
and racial purposes. A half hour’s reading in The Encyclopedia of
Bioethics , under “human experimentation,” “minority subjects,”
reveals that it had been thus for half a century. The Encyclopedia
documents cases of experimentation on human beings of minority
populations and Third World populations.
Eileen Welsome’s book, “The Plutonium Files,” (Dial Press, 1999),
documents radiation experiments on human beings in the United
States from the 1940s, after the exposure of Nazi experiments and
the articulation of the Nuremburg Code. Some of the doctors who
conducted these experiments and were later interviewed about them,
confessed that they knew of the Nuremberg Code, but did not think
it applied to them–that code was for the barbarian Nazis.
William Silverman of Columbia University, said:
“‘The connection between those horrendous acts and our every day
investigation was not made for reasons of self interest, to be
perfectly frank. As I see it now, I’m saddened that I didn’t see
the connection, but that’s what was sone. We wrapped ourselves in
the flag….’” (p. 214.)
“Physicians performed experiments on healthy people and sick
patients without informing them of what was going on or getting
their consent. Sick patients were preyed on most frequently. They
were convenient, plentiful, and vulnerable, since non-therapeutic
procedures could be administered easily under the guise of medical
Terminally ill patients were perhaps the most vulnerable group of
all… Women, children, unborn fetuses, minorities, the mentally
retarded, schizophrenics, prisoners, alcoholics, and poor people of
all ages and ethnic groups were targets.” (p. 214-215)
There are examples of experimentation on human beings that is more
democratic. Ed Regis’ book, “The Biology of Doom: The History of
America’s Secret Germ Warfare Project,” ( Henry Holt & Co., 2,000)
writes of those experiments when U.S. Nay ships,
“without, it seems the knowledge of Congress, sprayed the Virginia
coastal communities of Norfolk, Hampton and Newport News with BG
(bacillus globigii–used to stimulate the spread of anthrax) [and]
800,000 people around San Francisco ay were exposed to clouds of
(“The New York Times Book Review, Jan. 22, 2,000).
Prior to this, in October, 1940,
“Japanese planes dropped a mixture of grains and fleas over Chinese
towns, causing two major outbreaks of bubonic plague south of
The race to develop genetic medicine has opened new temptations for
doctors to experiment on human beings.
The death of Jesse Gelsinger, 18 years old, who suffered from a non-
threatening liver ailment, and was induced to undergo genetic
treatment for it at the University of Pennsylvania, has exposed
appalling practices that are now a century old: the cavalier
behavior of the experimenters, the hasty patched-together “informed
consent” form –after his death— other procedural misconduct.
(“The New York Times, Jan. 27, 2,000, page. 1, ” Youth’s Death
Shaking Up Field of Gene Experiments on Humans.)
The philosopher Hans Jonas proposed that experimentation on human
beings must be reserved not for the disenfranchised, but for the
scientists and intellectuals themselves — both for scientific and
moral reasons. Scientifically, because the class that designs the
experiments can best report on the probity and results of the
There were outstanding examples of this procedure in the nineteenth
century, and occasionally one still hears of a medical doctor
experimenting on himself (or a member of his family), but as human
experimentation went from what David Rothman called “a cottage
industry” in the nineteenth century to its present dimensions as an
indispensable part of modern medicine requiring ever larger
populations, “voluntary science martyrs” disappeared.
The reasons for this are not hard to find: If Mary Rafferty had
understood what she presumably was consenting to, she would not
likely have consented. Some who do consent are usually those in
desperately dependent positions.
Jerome Stephens offers another, more chilling reason why the
medical research community does not seek out “volunteers’ from the
higher socio-economic brackets.
Researching on the ignorant and the disenfranched allows the
researchers to maintain control of the research process.
“Medical researchers, of course, are quite aware of the social,
economic, and political backgrounds of those who serve as subjects,
and while the researchers are interested in developing an ideology
that does imply societal authority for experimentation, the primary
goal seems to be to maintain their power over the neglected.
It is highly unlikely, for example, that researchers would even
want to include large numbers of educated and affluent individuals
as subjects, because to do so would almost certainly threaten the
status quo by requiring that more information be imparted, and by
requiring research to be better designed to avoid the completely
useless experiments now conducted.
It is also obvious that more stringent regulations would emerge to
control experimentation if groups with well-defined and powerful
constituencies were used. At the present, the researchers, by
confining their experiments primarily to the neglected, are
potentially useful to the more affluent in that they may discover
new knowledge, and the researchers provide no threat to the middle
Tacit consent to exercise power, then, does reside in researchers,
but it is the exercise of power, not individual choice to submit to
experimentation or overt societal authority that is the core to
understanding the whole process of human experimentation.”
Animal experimentation is “the core to understanding the whole
process of human experimentation,” for if the poor, the mentally
retarded, the homeless, the orphaned and the imprisoned have little
voice, the animals have no voice, and it is voicelessness and
rightlessness that invests the whole procedure from animal to
orphan to the mentally retarded.
We are not done with Auschwitz and Nuremberg. Their shadows are
The silence of the medical communities in Germany and the United
States after the Second World War revealed the desire of the
medical communities to distance themselves from the outrages of
Auschwitz, by silence and by spreading the myth that the German
experiments was the work of deranged scientists.
In his anthology, When Medicine Went Mad, Arthur Caplan asks why
bioethics has so little so say about the Holocaust:
“There has been almost no discussion of the roles played by
medicine and science during the Nazi era in bioethic literature.
Rather than see Nazi biomedicine as morally bad, the field of
bioethics has generally accepted the myths that Nazi medicine was
either inept, mad, or coerced.
By subscribing to these myths, bioethics has been able to avoid a
painful confrontation with the fact that many who committed the
crimes of the Holocaust were competent physicians and health care
professionals acting from their moral convictions…. A fog of
excuses, lies, and exculpation has been laid over the crematoria
and laboratories of the concentration camps.”
When the Nazi doctors were asked in the Nuremberg trials how they
could have brought themselves to perform such experiments, they
responded that they had been trained by doing them on animals.
Time is exposing the desperate myth that animal experimentation
replaces or disposes of the need for human experimentation, and
that the work of the Nazi doctors was that of “mad scientists.”
Some of it was bad science, but some of it wasn’t, and the work of
the Nazi doctors has been entering mainstream Western medicine for
The Columbus Dispatch in 1984 revealed that a researcher in British
Columbia had been using the information from Nazi experiments on
hypothermia. The Jerusalem Report of Feb. 22, 1996 revealed that
Dr. Howard Israel, an oral surgeon at Columbia Presbyterian Medical
Center in New York was dismayed to discover that his valuable and
trusted book, Pernkopf’s Topographical and Applied Human Anatomy
contained illustrations that may be based on the cadavers of
concentration camp victims.
Caplan’s question in When Medicine Went Mad, “Should Nazi data from
the experiments be used?” has been answered: Nazi data has been
used by many scientists from many nations.
Our moral horror at the Nazi medical experiments was dissipated by
our government’s decision not to prosecute the Japanese for almost
identical experiments on an almost identical number of victims,
three thousand (many of whom were American prisoners), in exchange
for the information from those experiments.
As Raoul Hillburg wrote in The Destruction of the European Jews,
“If the world was so shocked at what it discovered to be the
extremes to which experimental medicine would go, it has yet to
condemn the method or find the means to control it.”
The Nuremberg Code (1947)
Permissible Medical Experiments
from CircumcisionReferenceLibrary Website
BRITISH MEDICAL JOURNAL
No 7070 Volume 313: Page 1448,
7 December 1996
The judgment by the war crimes tribunal at Nuremberg laid down 10
standards to which physicians must conform when carrying out
experiments on human subjects in a new code that is now accepted
This judgment established a new standard of ethical medical
behavior for the post World War II human rights era. Amongst other
requirements, this document enunciates the requirement of voluntary
informed consent of the human subject. The principle of voluntary
informed consent protects the right of the individual to control
his own body.
This code also recognizes that the risk must be weighed against the
expected benefit, and that unnecessary pain and suffering must be
This code recognizes that doctors should avoid actions that injure
The principles established by this code for medical practice now
have been extended into general codes of medical ethics.
The great weight of the evidence before us to effect that certain
types of medical experiments on human beings, when kept within
reasonably well-defined bounds, conform to the ethics of the
medical profession generally.
The protagonists of the practice of human experimentation justify
their views on the basis that such experiments yield results for
the good of society that are unprocurable by other methods or means
All agree, however, that certain basic principles must be observed
in order to satisfy moral, ethical and legal concepts:
The voluntary consent of the human subject is absolutely essential.
This means that the person involved should have legal capacity to
give consent; should be so situated as to be able to exercise free
power of choice, without the intervention of any element of force,
fraud, deceit, duress, overreaching, or other ulterior form of
constraint or coercion; and should have sufficient knowledge and
comprehension of the elements of the subject matter involved as to
enable him to make an understanding and enlightened decision.
This latter element requires that before the acceptance of an
affirmative decision by the experimental subject there should be
made known to him the nature, duration, and purpose of the
experiment; the method and means by which it is to be conducted;
all inconveniences and hazards reasonably to be expected; and the
effects upon his health or person which may possibly come from his
participation in the experiment.
The duty and responsibility for ascertaining the quality of the
consent rests upon each individual who initiates, directs, or
engages in the experiment. It is a personal duty and responsibility
which may not be delegated to another with impunity.
The experiment should be such as to yield fruitful results for the
good of society, unprocurable by other methods or means of study,
and not random and unnecessary in nature.
The experiment should be so designed and based on the results of
animal experimentation and a knowledge of the natural history of
the disease or other problem under study that the anticipated
results justify the performance of the experiment.
The experiment should be so conducted as to avoid all unnecessary
physical and mental suffering and injury.
No experiment should be conducted where there is an a priori reason
to believe that death or disabling injury will occur; except,
perhaps, in those experiments where the experimental physicians
also serve as subjects.
The degree of risk to be taken should never exceed that determined
by the humanitarian importance of the problem to be solved by the
Proper preparations should be made and adequate facilities provided
to protect the experimental subject against even remote
possibilities of injury, disability or death.
The experiment should be conducted only by scientifically qualified
persons. The highest degree of skill and care should be required
through all stages of the experiment of those who conduct or engage
in the experiment.
During the course of the experiment the human subject should be at
liberty to bring the experiment to an end if he has reached the
physical or mental state where continuation of the experiment seems
to him to be impossible.
During the course of the experiment the scientist in charge must be
prepared to terminate the experiment at any stage, if he has
probable cause to believe, in the exercise of the good faith,
superior skill and careful judgment required of him, that a
continuation of the experiment is likely to result in injury,
disability, or death to the experimental subject.
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